Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples

Forinová, Michala; Pilipenco, Alina; Víšová, Ivana; Lynn, Nicholas Scott; Dostálek, Jakub; Mašková, H.; Hönig, Václav; Palus, Martin; Selinger, Martin; Kočová, P.; Dyčka, F.; Štěrba, J.; Houska, Milan; Vrabcová, Markéta; Horák, Petr; Anthi, Judita; Tung, C.P.; Yu, C.M.; Chen, C.Y.; Huang, Y.C.; Tsai, P.H.; Lin, S.Y.; Hsu, H.J.; Yang, A.S.; Dejneka, Alexandr; Vaisocherová-Lísalová, Hana

doi:https://dx.doi.org/10.1021/acsami.1c16930

Number of the records: 1

Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples

1.

SYSNO ASEP	0552755
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples
Author(s)	Forinová, Michala (FZU-D)_ORCID Pilipenco, Alina (FZU-D)_{ORCID, RID} Víšová, Ivana (FZU-D)_ORCID Lynn, Nicholas Scott (FZU-D)_ORCID Dostálek, Jakub (FZU-D)_ORCID Mašková, H. (CZ) Hönig, Václav (BC-A)_{RID, ORCID} Palus, Martin (BC-A)_{RID, ORCID} Selinger, Martin (BC-A)_RID Kočová, P. (CZ) Dyčka, F. (CZ) Štěrba, J. (CZ) Houska, Milan (FZU-D)_ORCID Vrabcová, Markéta (FZU-D)_ORCID Horák, Petr (FZU-D)_ORCID Anthi, Judita (FZU-D)_ORCID Tung, C.P. (TW) Yu, C.M. (TW) Chen, C.Y. (TW) Huang, Y.C. (TW) Tsai, P.H. (TW) Lin, S.Y. (TW) Hsu, H.J. (TW) Yang, A.S. (TW) Dejneka, Alexandr (FZU-D)_{RID, ORCID} Vaisocherová-Lísalová, Hana (FZU-D)_ORCID
Number of authors	26
Source Title	ACS Applied Materials and Interfaces. - : American Chemical Society - ISSN 1944-8244 Roč. 13, č. 50 (2021), s. 60612-60624
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	functional coatings ; polymer brush ; zwitterionic materials ; SARS-CoV-2 ; piezoelectric biosensor ; rapid detection
Subject RIV	BO - Biophysics
OECD category	Biochemical research methods
Subject RIV - cooperation	Biology Centre (since 2006) - Epidemiology, Contagious Diseases ; Clinical Immunology
R&D Projects	EF18_053/0016627 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA21-19779S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	FZU-D - RVO:68378271 ; BC-A - RVO:60077344
UT WOS	000731597600001
EID SCOPUS	85121692024
DOI	10.1021/acsami.1c16930
Annotation	New analytical techniques that overcome major drawbacks of current routinely used viral infection diagnosis methods, i.e., the long analysis time and laboriousness of real-time reversetranscription polymerase chain reaction (qRT-PCR) and the insufficient sensitivity of “antigen tests”, are urgently needed in the context of SARS-CoV-2 and other highly contagious viruses. Here, we report on an antifouling terpolymer-brush biointerface that enables the rapid and sensitive detection of SARSCoV-2 in untreated clinical samples. The developed biointerface carries a tailored composition of zwitterionic and non-ionic moieties and allows for the significant improvement of antifouling capabilities when postmodified with biorecognition elements and exposed to complex media.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2022
Electronic address	https://doi.org/10.1021/acsami.1c16930

Number of the records: 1