Number of the records: 1  

Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples

  1. 1.
    SYSNO ASEP0552755
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleFunctionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples
    Author(s) Forinová, Michala (FZU-D) ORCID
    Pilipenco, Alina (FZU-D) ORCID, RID
    Víšová, Ivana (FZU-D) ORCID
    Lynn, Nicholas Scott (FZU-D) ORCID
    Dostálek, Jakub (FZU-D) ORCID
    Mašková, H. (CZ)
    Hönig, Václav (BC-A) RID, ORCID
    Palus, Martin (BC-A) RID, ORCID
    Selinger, Martin (BC-A) RID
    Kočová, P. (CZ)
    Dyčka, F. (CZ)
    Štěrba, J. (CZ)
    Houska, Milan (FZU-D) ORCID
    Vrabcová, Markéta (FZU-D) ORCID
    Horák, Petr (FZU-D) ORCID
    Anthi, Judita (FZU-D) ORCID
    Tung, C.P. (TW)
    Yu, C.M. (TW)
    Chen, C.Y. (TW)
    Huang, Y.C. (TW)
    Tsai, P.H. (TW)
    Lin, S.Y. (TW)
    Hsu, H.J. (TW)
    Yang, A.S. (TW)
    Dejneka, Alexandr (FZU-D) RID, ORCID
    Vaisocherová-Lísalová, Hana (FZU-D) ORCID
    Number of authors26
    Source TitleACS Applied Materials and Interfaces. - : American Chemical Society - ISSN 1944-8244
    Roč. 13, č. 50 (2021), s. 60612-60624
    Number of pages13 s.
    Languageeng - English
    CountryUS - United States
    Keywordsfunctional coatings ; polymer brush ; zwitterionic materials ; SARS-CoV-2 ; piezoelectric biosensor ; rapid detection
    Subject RIVBO - Biophysics
    OECD categoryBiochemical research methods
    Subject RIV - cooperationBiology Centre (since 2006) - Epidemiology, Contagious Diseases ; Clinical Immunology
    R&D ProjectsEF18_053/0016627 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    GA21-19779S GA ČR - Czech Science Foundation (CSF)
    Method of publishingLimited access
    Institutional supportFZU-D - RVO:68378271 ; BC-A - RVO:60077344
    UT WOS000731597600001
    EID SCOPUS85121692024
    DOI10.1021/acsami.1c16930
    AnnotationNew analytical techniques that overcome major drawbacks of current routinely used viral infection diagnosis methods, i.e., the long analysis time and laboriousness of real-time reversetranscription polymerase chain reaction (qRT-PCR) and the insufficient sensitivity of “antigen tests”, are urgently needed in the context of SARS-CoV-2 and other highly contagious viruses. Here, we report on an antifouling terpolymer-brush biointerface that enables the rapid and sensitive detection of SARSCoV-2 in untreated clinical samples. The developed biointerface carries a tailored composition of zwitterionic and non-ionic moieties and allows for the significant improvement of antifouling capabilities when postmodified with biorecognition elements and exposed to complex media.
    WorkplaceInstitute of Physics
    ContactKristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
    Year of Publishing2022
    Electronic addresshttps://doi.org/10.1021/acsami.1c16930
Number of the records: 1  

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