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3D hepatic tumor cell culture plasticity mediated by YAPmTOR axis
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SYSNO ASEP 0551998 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title 3D hepatic tumor cell culture plasticity mediated by YAPmTOR axis Author(s) Frtús, Adam (FZU-D) ORCID
Smolková, Barbora (FZU-D) ORCID
Uzhytchak, Mariia (FZU-D) ORCID
Lunova, M. (CZ)
Petrenko, Yuriy (UEM-P) RID, ORCID
Kubinová, Šárka (UEM-P) RID, ORCID
Dejneka, Alexandr (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCIDNumber of authors 8 Source Title FEBS Open Bio, 11. - Amsterdam : Wiley, 2021 - ISSN 2211-5463
S. 376-376Number of pages 1 s. Publication form Print - P Action FEBS Congress, Molecules of Life: Towards New Horizons /45./ Event date 03.07.2021 - 08.07.2021 VEvent location online Event type WRD Language eng - English Country NL - Netherlands Keywords mitochondria ; laser irradiation ; cell death Subject RIV BO - Biophysics OECD category Biophysics Subject RIV - cooperation Institute of Experimental Medicine Institutional support FZU-D - RVO:68378271 ; UEM-P - RVO:68378041 DOI 10.1002/2211-5463.13205 Annotation High fluence lowpower (HFLP) lasers has been recognized as a promising tool for treatment of various pathological conditions.In addition, the precise molecular mechanisms of laser light on cells remain elusive. In addition, HFLP laser irradiation is widely used in superresolution localization microscopy. However, side effects of laser irradiation are largely ignored. A better understanding of the molecular mechanisms of HFLP lasercell interaction will be an instrumental for the development of novel therapeutic modalities. Therefore, we studied subcellular mechanisms involved in the laser interaction with human hepatic cell lines. We compared the effects of different laser wavelengths (398nm, 505nm, 650nm) on three various human liver cancer cell lines (Huh7, HepG2, Alexander). Our results revealed mitochondria as a subcellular “sensor” and “effector” of laser light nonspecific interactions with cells. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022
Number of the records: 1