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Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase
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SYSNO ASEP 0550795 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Two Novel Semisynthetic Lipoglycopeptides Active against Staphylococcus aureus Biofilms and Cells in Late Stationary Growth Phase Author(s) Vimberg, Vladimír (MBU-M) ORCID
Zieglerová, Leona (MBU-M) ORCID
Mazumdar, Aninda (MBU-M)
Szucs, Z. (HU)
Borbas, A. (HU)
Herczegh, P. (HU)
Balíková Novotná, Gabriela (MBU-M) ORCIDArticle number 1182 Source Title Pharmaceuticals. - : MDPI
Roč. 14, č. 11 (2021)Number of pages 12 s. Language eng - English Country CH - Switzerland Keywords antibiotic resistance ; glycopeptide antibiotics ; Staphylococcus aureus ; teicoplanin pseudoaglycon Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects NV15-28807A GA MZd - Ministry of Health (MZ) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000726030300001 EID SCOPUS 85122064512 DOI 10.3390/ph14111182 Annotation The increase in antibiotic resistance among Gram-positive bacteria underscores the urgent need to develop new antibiotics. New antibiotics should target actively growing susceptible bacteria that are resistant to clinically accepted antibiotics including bacteria that are not growing or are protected in a biofilm environment. In this paper, we compare the in vitro activities of two new semisynthetic glycopeptide antibiotics, MA79 and ERJ390, with two clinically used glycopeptide antibiotics-vancomycin and teicoplanin. The new antibiotics effectively killed not only exponentially growing cells of Staphylococcus aureus, but also cells in the stationary growth phase and biofilm. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2022 Electronic address https://www.mdpi.com/1424-8247/14/11/1182
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