Number of the records: 1
Rozdíly v elektrochemické redukci jedno- a vícejaderných acylgermanů
- 1.0549348 - ÚFCH JH 2024 RIV CZ cze C - Conference Paper (international conference)
Šimková, Ludmila - Dunlop, David - Liška, Alan - Ludvík, Jiří
Rozdíly v elektrochemické redukci jedno- a vícejaderných acylgermanů.
[Differences in Electrochemical Reduction of Mono- and Polynuclear Acylgermanes.]
Sborník přednášek mezinárodní odborné konference XL. Moderní Elektrochemické Metody. Ústí nad Labem: Best Servis, 2021 - (Navrátil, T.; Fojta, M.; Schwarzová, K.), s. 234-238. ISBN 978-80-905221-8-3.
[Moderní Elektrochemické Metody /40./. Jetřichovice (CZ), 08.11.2021-12.11.2021]
R&D Projects: GA ČR(CZ) GA17-05838S
Institutional support: RVO:61388955
Keywords : Titanocene derivatives * Tuning of redox behavior * Substitution of cyclopentadienyl ring
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Derivaty titanocenu nachazeji bohate vyuziti jako katalyzatory pri cele fade chemickych
transformaci. Nicmene v posledni dobe se zkouma i jejich potencialni vyuziti jako cytostatik
pri lecbe onkologickych onemocneni. Nedavne studie poukazaly na vyssi cytotoxicitu u cele
fady titanocen difluoridovych derivatu v porovnani s jejich dichloridovymi analogy.
Nasledne zkoumani mechanismu ucinku titanocemi poukazalo na rozpad endoplasmatickeho
retikula rakovinnych bunek pusobenim reaktivnich kyslikovych castic (ROS). Tyto castice
generovane pomoci redoxne aktivnich kovu (v nasem pripade titanocenu) muzou byt ucinnym
prostredkem pro selektivni likvidaci rakovinovych bunek, jejichz homeostaza je na pritomnost
ROS citlivejsi V porovnani se zdravymi bunkami.
Recently, titanocene derivatives have been investigated in term of their potential use as
cytostatics in the treatment of oncological diseases. The potentials for reduction or oxidation of
individual substances are one of the key properties which fundamentally affect the cytostatic
efficiency. Our previous results led us to investigate the redox properties of series of titanocene
difluoride and dichloride derivatives. This study is mainly focused on the effect of the
substitution of cyclopentadienyl ring and the halide anion on the redox properties of the
derivative.
Permanent Link: http://hdl.handle.net/11104/0325360
File Download Size Commentary Version Access 0549348.pdf 0 2.4 MB Publisher’s postprint require
Number of the records: 1