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The proton-boron reaction increases the radiobiological effectiveness of clinical low- and high-energy proton beams: novel experimental evidence and perspectives
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SYSNO ASEP 0546800 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The proton-boron reaction increases the radiobiological effectiveness of clinical low- and high-energy proton beams: novel experimental evidence and perspectives Author(s) Bláha, P. (IT)
Feoli, Ch. (IT)
Agosteo, S. (IT)
Calvaruso, M. (IT)
Cammarata, F.P. (IT)
Catalano, R. (IT)
Ciocca, M. (IT)
Cirrone, G. A. P. (IT)
Conte, V. (IT)
Cuttone, G. (IT)
Faceoetti, A. (IT)
Forte, G.I. (IT)
Giuffrida, Lorenzo (FZU-D) ORCID
Magro, G. (IT)
Margarone, Daniele (FZU-D) RID, ORCID
Minafra, L. (IT)
Petringa, Giada (FZU-D) ORCID
Pucci, G. (IT)
Ricciardi, V. (IT)
Rosa, E. (IT)
Russo, G. (IT)
Manti, L. (IT)Number of authors 22 Article number 682647 Source Title Frontiers in Oncology. - : Frontiers Research Foundation - ISSN 2234-943X
Roč. 11, Jun (2021)Number of pages 18 s. Language eng - English Country CH - Switzerland Keywords protontherapy ; chromosome aberrations ; proton-boron (B) fusion-enhanced proton therapy (PBFEPT) ; BSH ; alpha-particle ; cancer cell killing Subject RIV BF - Elementary Particles and High Energy Physics OECD category Particles and field physics R&D Projects EF20_079/0017754 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) TP01010035 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Research Infrastructure ELI Beamlines III - 90141 - Fyzikální ústav AV ČR, v. v. i. Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000671897000001 EID SCOPUS 85110189769 DOI 10.3389/fonc.2021.682647 Annotation Protontherapy is a rapidly expanding radiotherapy modality where accelerated proton beams are used to precisely deliver the dose to the tumor target but is generally considered ineffective against radioresistant tumors. Proton-Boron Capture Therapy (PBCT) is a novel approach aimed at enhancing proton biological effectiveness. PBCT exploits a nuclear fusion reaction between low-energy protons and 11B atoms, i.e. p+11B→ 3α (p-B), which is supposed to produce highly-DNA damaging α-particles exclusively across the tumor-conformed Spread-Out Bragg Peak (SOBP), without harming healthy tissues in the beam entrance channel. To confirm previous work on PBCT, here we report new in-vitro data obtained at the 62-MeV ocular melanoma-dedicated proton beamline of the INFN-Laboratori Nazionali del Sud (LNS), Catania, Italy. For the first time, we also tested PBCT at the 250-MeV proton beamline used for deep-seated cancers at the Centro Nazionale di Adroterapia Oncologica (CNAO), Pavia, Italy.
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0323276
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