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Detection of neural light-scattering activity in vivo: optical transmittance studies in the rat brain
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SYSNO ASEP 0545856 Document Type J - Journal Article R&D Document Type The record was not marked in the RIV Subsidiary J Článek ve WOS Title Detection of neural light-scattering activity in vivo: optical transmittance studies in the rat brain Author(s) Pan, W.J. (US)
Lee, S. Y. (US)
Billings, Jacob (UIVT-O) SAI, ORCID, RID
Nezafati, M. (US)
Majeed, W. (US)
Buckley, E. (US)
Keilholz, S. (US)Number of authors 7 Source Title Neuroimage. - : Elsevier - ISSN 1053-8119
Roč. 179 (2018), s. 207-214Language eng - English Country US - United States Keywords imaging spectroscopy ; water diffusion ; cell-volume ; signals ; cortex ; fmri ; mri ; Intrinsic optical signal ; Neural scattering activity ; Neurovascular coupling ; Optical transmission measurement ; In vivo UT WOS 000438951400018 EID SCOPUS 85048816334 DOI 10.1016/j.neuroimage.2018.06.039 Annotation Optical studies of ex vivo brain slices where blood is absent show that neural activity is accompanied by significant intrinsic optical signals (IOS) related to activity-dependent scattering changes in neural tissue. However, the neural scattering signals have been largely ignored in vivo in widely-used IOS methods where absorption contrast from hemoglobin was employed. Changes in scattering were observed on a time scale of seconds in previous brain slice IOS studies, similar to the time scale for the hemodynamic response. Therefore, potential crosstalk between the scattering and absorption changes may not be ignored if they have comparable contributions to IOS. In vivo, the IOS changes linked to neural scattering have been elusive. To isolate neural scattering signals in vivo, we employed 2 implantable optodes for small-separation (2 mm) transmission measurements of local brain tissue in anesthetized rats. This unique geometry enables us to separate neuronal activity-related changes in neural tissue scattering from changes in blood absorption based upon the direction of the signal change. The changes in IOS scattering and absorption in response to up-states of spontaneous neuronal activity in cortical or subcortical structures have strong correlation to local field potentials, but significantly different response latencies. We conclude that activity-dependent neural tissue scattering in vivo may be an additional source of contrast for functional brain studies that provides complementary information to other optical or MR-based systems that are sensitive to hemodynamic contrast. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2022
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