Biomedical Nanomaterials

0545664 - ÚMCH 2023 RIV DE eng M - Monography Chapter
Zasońska, Beata Anna - Horák, Daniel
Magnetic iron oxide particles for theranostics.
Biomedical Nanomaterials. Cham: Springer, 2022 - (Stoika, R.), s. 95-115. ISBN 978-3-030-76234-6
R&D Projects: GA ČR(CZ) GC20-02177J
Institutional support: RVO:61389013
Keywords : magnetic particles * iron oxide * drug delivery
OECD category: Polymer science
https://link.springer.com/chapter/10.1007%2F978-3-030-76235-3_4

For many years, magnetic particles attracted a lot of interest in many fields, mainly including biomedicine. Recently, development of innovative strategies to tune the unique properties of magnetic nanoparticles for specific applications as theranostic agents has become one of the most challenging goals. This paper provides an overview of the synthesis, modification, and functionalization of magnetic nano- and microparticles. Special attention was paid to iron oxide composites used in cell separations and theranostics, such as anticancer drug delivery, diagnosis, and/or therapy of autoimmune and brain disorders. Last, but not the least, phenolic compound-modified magnetic particles were used as antioxidants or silver-containing carriers as antibacterial agents in in vitro and in vivo studies. Magnetic microparticles can be also incorporated in biosensors, exemplified by thionine-conjugated magnetic poly(carboxymethyl methacrylate-co-ethylene dimethacrylate) particles that showed higher enzymatic activity than nonmagnetic particles. Magnetic nano- and microparticles were characterized by a range of physicochemical methods, including transmission electron microscopy, dynamic light scattering, vibrating sample magnetometry, and Fourier-transform infrared spectroscopy, in terms of determination of particle morphology (size and its distribution), specific surface area, magnetic, and chemical properties. The chemical composition and crystallinity were confirmed by X-ray photoelectron spectroscopy. Moreover, the interactions between the magnetic particles and cells and/or other biological species were described.
Permanent Link: https://hdl.handle.net/11104/0338359