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Molecular architecture of the endocytic TPLATE complex
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SYSNO ASEP 0545616 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Molecular architecture of the endocytic TPLATE complex Author(s) Yperman, K. (BE)
Wang, J. (BE)
Eeckhout, D. (BE)
Winkler, J. (BE)
Vu, L. D. (BE)
Vandorpe, M. (BE)
Grones, P. (BE)
Mylle, E. (BE)
Kraus, M. (DE)
Merceron, R. (BE)
Nolf, J. (BE)
Mor, E. (BE)
de Bruyne, B. (BE)
Loris, Remy (UEB-Q) ORCID
Potocký, Martin (UEB-Q) RID, ORCID
Savvides, S. N. (BE)
De Rybel, B. (NL)
De Jaeger, G. (BE)
Van Damme, D. (BE)
Pleskot, Roman (UEB-Q) RID, ORCIDNumber of authors 20 Article number eabe7999 Source Title Science Advances. - : American Association for the Advancement of Science - ISSN 2375-2548
Roč. 7, č. 9 (2021)Number of pages 16 s. Language eng - English Country US - United States Keywords Cell membranes ; Molecular architecture ; Structural elucidation OECD category Cell biology R&D Projects GA19-21758S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000622481300035 EID SCOPUS 85102035889 DOI 10.1126/sciadv.abe7999 Annotation Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as an endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, we reveal the molecular architecture of plant TSET [TPLATE complex (TPC)] using an integrative structural approach. We identify crucial roles for specific TSET subunits in complex assembly and membrane interaction. Our data therefore generate fresh insight into the differences between the hexameric TSET in Dictyostelium and the octameric TPC in plants. Structural elucidation of this ancient adaptor complex represents the missing piece in the coatomer puzzle and vastly advances our functional as well as evolutionary insight into the process of endocytosis. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2022 Electronic address http://doi.org/10.1126/sciadv.abe7999
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