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Cationic polymer-coated magnetic nanoparticles with antibacterial properties: synthesis and in vitro characterization
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SYSNO ASEP 0545226 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cationic polymer-coated magnetic nanoparticles with antibacterial properties: synthesis and in vitro characterization Author(s) Shatan, Anastasiia-Bohdana (UMCH-V) RID, ORCID
Patsula, Vitalii (UMCH-V) RID, ORCID
Dydowiczová, Aneta (UMCH-V) ORCID
Gunár, Kristýna (UMCH-V) RID, ORCID
Velychkivska, Nadiia (UMCH-V) RID, ORCID
Hromádková, Jiřina (UMCH-V) RID
Petrovský, Eduard (GFU-E) ORCID, RID
Horák, Daniel (UMCH-V) RID, ORCIDArticle number 1077 Source Title Antibiotics (Basel). - : MDPI - ISSN 2079-6382
Roč. 10, č. 9 (2021)Number of pages 15 s. Language eng - English Country CH - Switzerland Keywords magnetic ; nanoparticles ; antibacterial activity Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Subject RIV - cooperation Geophysical Institute - Earth Magnetism, Geodesy, Geography R&D Projects GC20-02177J GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 ; GFU-E - RVO:67985530 UT WOS 000699057700001 EID SCOPUS 85114791185 DOI 10.3390/antibiotics10091077 Annotation Uniformly sized magnetite nanoparticles (Dn = 16 nm) were prepared by a thermal decomposition of Fe(III) oleate in octadec-1-ene and stabilized by oleic acid. The particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups available for the attachment to the iron oxide and at the same time enabling (co)polymerization of 2-(dimethylamino)ethyl methacrylate and/or 2-tert-butylaminoethyl methacrylate at two molar ratios. The poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and poly[2-(dimethylamino)ethyl methacrylate-co-2-tert-butylaminoethyl methacrylate] [P(DMAEMA-TBAEMA)] polymers and the particles were characterized by 1H NMR spectroscopy, size-exclusion chromatography, transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, magnetometry, and ATR FTIR and atomic absorption spectroscopy. The antimicrobial effect of cationic polymer-coated magnetite nanoparticles tested on both Escherichia coli and Staphylococcus aureus bacteria was found to be time- and dose-responsive. The P(DMAEMA-TBAEMA)-coated magnetite particles possessed superior biocidal properties compared to those of P(DMAEMA)-coated one. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.mdpi.com/2079-6382/10/9/1077
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