0545023 - ÚIACH 2022 RIV CH eng J - Journal Article
Germano, J. F. - Sharma, A. - Šťastná, Miroslava - Huang, C. - Aniag, M. - Aceves, A. - Van Eyk, J.E. - Mentzer, R. M. - Piplani, H. - Andres, A. M. - Gottlieb, R. A.
Proteomics of mouse heart ventricles reveals mitochondria and metabolism as major targets of a post-infarction short-acting glp1ra-therapy.
International Journal of Molecular Sciences. Roč. 22, č. 16 (2021), č. článku 8711. ISSN 1422-0067. E-ISSN 1422-0067
Institutional support: RVO:68081715
Keywords : glucagon-like peptide-1 receptor agonists (GLP1Ras) * proteomics * early cardiac remodeling
OECD category: Analytical chemistry
Impact factor: 6.208, year: 2021 ; AIS: 1.064, rok: 2021
Method of publishing: Limited access
DOI: https://doi.org/10.3390/ijms22168711

The global proteomics was employed to interrogate the target proteins, organelles and biological processes affected by short-acting GLP1Ra administered after permanent coronary artery ligation (PCAL).This approach showed a central role for mitochondria and mitochondria-associated metabolic pathways, such as fatty acid oxidation, in the beneficial effects of short-acting GLP1Ra on postinfarttion remodeling. The overexpression of proteins identified by protein-protein interaction networks, such as Atp2a2, may be important to the mechanism of action of GLP1Ra.
Permanent Link: http://hdl.handle.net/11104/0321801