Voltammetry of Several Natural and Synthetic Opioids at a Polarized Ionic Liquid Membrane

0544237 - ÚFCH JH 2022 RIV DE eng J - Journal Article
Langmaier, Jan - Maier, V. - Samec, Zdeněk
Voltammetry of Several Natural and Synthetic Opioids at a Polarized Ionic Liquid Membrane.
ChemElectroChem. Roč. 8, č. 13 (2021), s. 2519-2525. ISSN 2196-0216. E-ISSN 2196-0216
R&D Projects: GA ČR(CZ) GA20-07350S
Institutional support: RVO:61388955
Keywords : standard gibbs energies * cyclic voltammetry * interface * electrochemistry * fentanyl * delivery * system * drugs * water * cyclic voltammetry * ionic liquids * lipophilicity * membranes * opioids
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Impact factor: 4.782, year: 2021
Method of publishing: Limited access

Cyclic voltammetry is used to examine the transfer of the protonated forms of several natural and synthetic opioids including fentanyl and its analogs, morphine, heroin and codeine, across the polarized interface between an aqueous electrolyte solution and an ionic liquid (IL) membrane. Besides demonstrating the possibility of an amperometric detection and determination, the voltammetric measurements provide the values of the ion partition coefficients and the standard Gibbs energy of ion transfer, along with the partition coefficients for the neutral opioids, which follow the sequence corresponding to the opioid analgesic potency. A correlation between the partition coefficients for the neutral and protonated opioids points to their common basis, which is the difference between the solvation energies of the partitioned species in water and IL phase. A comparison of the experimental and theoretical values of the standard Gibbs energy of ion transfer suggests that the solvophobic interactions play a key role.
Permanent Link: http://hdl.handle.net/11104/0321267