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Fabrication of a glycerol-citrate polymer coated tricalcium phosphate bone cements: structural investigation and material properties
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SYSNO ASEP 0543306 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fabrication of a glycerol-citrate polymer coated tricalcium phosphate bone cements: structural investigation and material properties Author(s) Sopčák, T. (SK)
Medvecký, L. (SK)
Giretová, M. (SK)
Stulajterova, R. (SK)
Brus, Jiří (UMCH-V) RID, ORCID
Urbanová, Martina (UMCH-V) RID, ORCID
Kromka, F. (SK)
Podobová, M. (SK)
Fáberová, M. (SK)Article number 231 Source Title Journal of Polymer Research. - : Springer - ISSN 1022-9760
Roč. 28, č. 6 (2021)Number of pages 16 s. Language eng - English Country TW - Taiwan, Province of China Keywords glycerol-citrate ; tricalcium phosphate ; elastomers Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000756714700004 EID SCOPUS 85107376953 DOI 10.1007/s10965-021-02596-w Annotation Calcium phosphate cements (CPCs) belong to one of the most prominent biomaterials used for filling and regeneration of hard tissues, however poor mechanical and biological properties limit their widespread use in some clinical applications. To solve these problems, a biodegradable glycerol-citrate (G-CA) polyester was synthesized and coated on tricalcium phosphate cement (TCP) powders in amounts up to 10 wt% of the G-CA content using a simple solution infiltration technique in ethanol solution. Chemical and structural analysis of the G-CA elastomer and TCP/G-CA composites were thoroughly analyzed with chromatographic techniques, solid-state nuclear magnetic resonance (ssNMR), differential scanning calorimetry and thermogravimetry (DSC/TG), X-ray diffraction (XRD), Fourier-Transform Infrared spectroscopy (FTIR) and field emission scanning electron microscopy (SEM). The results demonstrated that the incorporation of 2.5 and 5 wt% of G-CA into TCP cement led to a significant increase of mechanical strength of the cements due to the formation of thin and homogeneous elastomer coating on cement particles, reinforcing the microstructure through hydrogen bonds between residual COOH groups of polymer and surface phosphate groups of the cement matrix. Additional in vitro testing of extracts cytotoxicity revealed a high proliferation of osteoblasts in all composites, demonstrating a promising application potential in regenerative medicine. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://link.springer.com/article/10.1007%2Fs10965-021-02596-w
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