Number of the records: 1
Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering
- 1.
SYSNO ASEP 0542997 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering Author(s) Zasońska, Beata Anna (UMCH-V) RID, ORCID
Brož, Antonín (FGU-C) RID, ORCID, SAI
Šlouf, Miroslav (UMCH-V) RID, ORCID
Hodan, Jiří (UMCH-V)
Petrovský, Eduard (GFU-E) ORCID, RID
Hlídková, Helena (UMCH-V) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCIDArticle number 1871 Source Title Polymers. - : MDPI
Roč. 13, č. 11 (2021)Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords poly(2-hydroxyethyl methacrylate) ; superporous ; scaffold Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Subject RIV - cooperation Institute of Physiology - Biotechnology ; Bionics
Geophysical Institute - Earth Magnetism, Geodesy, GeographyR&D Projects GA20-07015S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 ; FGU-C - RVO:67985823 ; GFU-E - RVO:67985530 UT WOS 000660535800001 EID SCOPUS 85108223800 DOI 10.3390/polym13111871 Annotation Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy confirmed that the hydrogels contained communicating pores with a length of ≤2 mm and thickness of ≤400 μm, the SEM/EDX microanalysis documented the presence of γ-Fe2O3 nanoparticles in the polymer matrix. The saturation magnetization of the magnetic hydrogel reached 2.04 Am2/kg, which corresponded to 3.7 wt.% of maghemite in the scaffold. The shape of the hysteresis loop and coercivity parameters suggested the superparamagnetic nature of the hydrogel. The highest toughness and compressive modulus were observed with γ-Fe2O3-loaded PHEMA hydrogels. Finally, the cell seeding experiments with the human SAOS-2 cell line showed a rather mediocre cell colonization on the PHEMA-based hydrogel scaffolds. However, the incorporation of γ-Fe2O3 nanoparticles into the hydrogel improved the cell adhesion significantly. This could make this composite a promising material for bone tissue engineering. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2022 Electronic address https://www.mdpi.com/2073-4360/13/11/1871
Number of the records: 1