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Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment
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SYSNO ASEP 0542909 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment Author(s) Budimir, M. (RS)
Marković, Z. (RS)
Vajďák, J. (CZ)
Jovanović, S. (RS)
Kubát, Pavel (UFCH-W) RID, ORCID, SAI
Humpolíček, P. (CZ)
Mičušik, M. (SK)
Danko, M. (SK)
Barras, A. (FR)
Milivojević, D. D. (RS)
Špitalsky, Z. (SK)
Boukherroub, R. (FR)
Marković, B. T. (RS)Article number 109499 Source Title Radiation Physics and Chemistry. - : Elsevier - ISSN 0969-806X
Roč. 185, AUG 2021 (2021)Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords Antibacterial photodynamic therapy ; Carbon quantum dots ; Gamma-irradiation ; Polymer-matrix composite ; Reactive oxygen species Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Method of publishing Limited access Institutional support UFCH-W - RVO:61388955 UT WOS 000655300100004 EID SCOPUS 85105360471 DOI 10.1016/j.radphyschem.2021.109499 Annotation Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0320242
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