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Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective
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SYSNO ASEP 0540034 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective Author(s) Smolková, B. (CZ)
Frtus, A. (CZ)
Uzhytchak, M. (CZ)
Lunova, M. (CZ)
Kubinová, Šárka (UEM-P) RID, ORCID
Dejneka, A. (CZ)
Lunov, O. (CZ)Article number 6226 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 21, č. 17 (2020)Number of pages 24 s. Language eng - English Country CH - Switzerland Keywords non-thermal plasma ; cytotoxicity ; cell signaling Subject RIV BO - Biophysics OECD category Biophysics R&D Projects FV10081 GA MPO - Ministry of Industry and Trade (MPO) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000569583400001 EID SCOPUS 85090179717 DOI 10.3390/ijms21176226 Annotation The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2021 Electronic address https://www.mdpi.com/1422-0067/21/17/6226
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