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Developmental variability channels mouse molar evolution
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SYSNO ASEP 0539946 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Developmental variability channels mouse molar evolution Author(s) Hayden, L. (FR)
Lochovská, K. (CZ)
Sémon, M. (FR)
Renaud, S. (FR)
Delignette-Müller, M.L. (FR)
Vilcot, M. (FR)
Peterková, R. (CZ)
Hovořáková, Mária (UEM-P) RID
Pantalacci, S. (FR)Article number e50103 Source Title eLife. - : eLife - ISSN 2050-084X
Roč. 9, feb. (2020)Number of pages 38 s. Language eng - English Country GB - United Kingdom Keywords tooth development ; 3-dimensional reconstruction ; phenotypic variation Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology R&D Projects GB14-37368G GA ČR - Czech Science Foundation (CSF) GA18-04859S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000529367300001 EID SCOPUS 85083813559 DOI 10.7554/eLife.50103 Annotation Do developmental systems preferentially produce certain types of variation that orient phenotypic evolution along preferred directions? At different scales, from the intra-population to the interspecific, the murine first upper molar shows repeated anterior elongation. Using a novel quantitative approach to compare the development of two mouse strains with short or long molars, we identified temporal, spatial and functional differences in tooth signaling center activity, that arise from differential tuning of the activation-inhibition mechanisms underlying tooth patterning. By tracing their fate, we could explain why only the upper first molar reacts via elongation of its anterior part. Despite a lack of genetic variation, individuals of the elongated strain varied in tooth length and the temporal dynamics of their signaling centers, highlighting the intrinsic instability of the upper molar developmental system. Collectively, these results reveal the variational properties of murine molar development that drive morphological evolution along a line of least resistance. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2021 Electronic address https://elifesciences.org/articles/50103
Number of the records: 1