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Complex Evolution of Insect Insulin Receptors and Homologous Decoy Receptors, and Functional Significance of Their Multiplicity
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SYSNO ASEP 0539924 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Complex Evolution of Insect Insulin Receptors and Homologous Decoy Receptors, and Functional Significance of Their Multiplicity Author(s) Smýkal, V. (CZ)
Pivarci, M. (CZ)
Provazník, J. (CZ)
Bazalova, O. (CZ)
Jedlička, Pavel (BFU-R) ORCID
Luksan, O. (CZ)
Horák, A. (CZ)
Vaněčková, H. (CZ)
Benes, V. (DE)
Fiala, I. (CZ)
Hanus, R. (CZ)
Doležel, D. (CZ)Number of authors 12 Source Title Molecular Biology and Evolution. - : Oxford University Press - ISSN 0737-4038
Roč. 37, č. 6 (2020), s. 1775-1789Number of pages 15 s. Publication form Print - P Language eng - English Country US - United States Keywords pyrrhocoris-apterus heteroptera ; extends life-span ; linden bug ; honey-bee ; caste development ; tyrosine kinases ; drosophila Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000569060900018 EID SCOPUS 85084206628 DOI 10.1093/molbev/msaa048 Annotation Evidence accumulates that the functional plasticity of insulin and insulin-like growth factor signaling in insects could spring, among others, from the multiplicity of insulin receptors (InRs). Their multiple variants may be implemented in the control of insect polyphenism, such as wing or caste polyphenism. Here, we present a comprehensive phylogenetic analysis of insect InR sequences in 118 species from 23 orders and investigate the role of three InRs identified in the linden bug, Pyrrhocoris apterus, in wing polymorphism control. We identified two gene clusters (Clusters I and II) resulting from an ancestral duplication in a late ancestor of winged insects, which remained conserved in most lineages, only in some of them being subject to further duplications or losses. One remarkable yet neglected feature of InR evolution is the loss of the tyrosine kinase catalytic domain, giving rise to decoys of InR in both clusters. Within the Cluster I, we confirmed the presence of the secreted decoy of insulin receptor in all studied Muscomorpha. More importantly, we described a new tyrosine kinase-less gene (DR2) in the Cluster II, conserved in apical Holometabola for similar to 300My. We differentially silenced the three P. apterus InRs and confirmed their participation inwing polymorphism control. We observed a pattern of Cluster I and Cluster II InRs impact on wing development, which differed from that postulated in planthoppers, suggesting an independent establishment of insulin/insulin-like growth factor signaling control over wing development, leading to idiosyncrasies in the co-option of multiple InRs in polyphenism control in different taxa. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://academic.oup.com/mbe/article/37/6/1775/5758269
Number of the records: 1