Potential for Treatment of Glioblastoma: New Aspects of Superparamagnetic Iron Oxide Nanoparticles

0538915 - ÚEM 2021 RIV GR eng J - Journal Article
Mareková, Dana - Turnovcová, Karolína - Susal, T.H. - Gandhi, Ch.D. - Jendelová, Pavla - Jhanwar-Uniyal, M.
Potential for Treatment of Glioblastoma: New Aspects of Superparamagnetic Iron Oxide Nanoparticles.
Anticancer Research. Roč. 40, č. 11 (2020), s. 5989-5994. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA ČR(CZ) GA17-04918S; GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : superparamagnetic iron oxide nanoparticles * SPION * glioblastoma
OECD category: Neurosciences (including psychophysiology
Impact factor: 2.480, year: 2020
Method of publishing: Limited access
https://ar.iiarjournals.org/content/40/11/5989

Glioblastoma (GB) is a highly aggressive and infiltrative brain tumor characterized by poor outcomes and a high rate of recurrence despite maximal safe resection, chemotherapy, and radiation. Superparamagnetic iron oxide nanoparticles (SPIONs) are a novel tool that can be used for many applications including magnetic targeting, drug delivery, gene delivery, hyperthermia treatment, cell tracking, or multiple simultaneous functions. SPIONs are studied as a magnetic resonance imaging tumor contrast agent by targeting tumor cell proteins or tumor vasculature. Drug delivery to GB tumor has been targeted with SPIONs in murine models. In addition to targeting tumor cells for imaging or drug-delivery, SPION has also been shown to be effective at targeting for hyperthermia. Along with animal models, human trials have been conducted for a number of different modes of SPION utilization, with important findings and lessons for further preclinical and clinical experiments. SPIONs are opening up several new avenues for monitoring and treatment of GB tumors, here, we review the current research and a variety of possible clinical applications.
Permanent Link: http://hdl.handle.net/11104/0316660