Sex Differences in Heart Disease

0537912 - FGÚ 2021 RIV CH eng M - Monography Chapter
Drahota, Zdeněk - Hlaváčková, Markéta - Ošťádal, Bohuslav
Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences.
Sex Differences in Heart Disease. Cham: Springer International Publishing, 2020 - (Dhalla, N.; Ošťádal, B.), s. 257-265. Advances in Biochemistry in Health and Disease, 21. ISBN 978-3-030-58676-8
R&D Projects: GA ČR(CZ) GJ19-04790Y
Institutional support: RVO:67985823
Keywords : sex * heart * mitochondria * ischemia/reperfusion injury * mitochondrial permeability transition pore
OECD category: Physiology (including cytology)
https://doi.org/10.1007/978-3-030-58677-5_15

It is now widely accepted that function of cardiac mitochondria is sex-dependent. Female mitochondria better utilize lipids and exhibit higher oxidative capacity in comparison with males. Our results have revealed that female cardiac mitochondria are more resistant to calcium-induced swelling as compared with the male myocardium, this suggests their better protection against mitochodrial permeability transition pore (PTP) opening.It seems to us that sex-dependent specificity of the PTP function is not the results of differences in its protein composition, since the male and female rat heart contains comparable amount of ATP synthase and its regulatory protein cyclophilinD (CypD). The higher hypoxic tolerance of the female cardiac mitochondria thus rather reflects sex differences in the regulation of PTP function, probably together with regulation of CypD by post-translational modifications. The precise knowledge of the composition of the PTP compex and regulation of pore opening are essential conditions for the development of new drugs targeting the function of PTP.
Permanent Link: http://hdl.handle.net/11104/0315750