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Sex Differences in Heart Disease
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SYSNO ASEP 0537904 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Sex Differences in Cardiac Ischemia/Reperfusion Injury Author(s) Ošťádal, Bohuslav (FGU-C) RID, ORCID
Ošťádal, P. (CZ)
Neckář, Jan (FGU-C) RID, ORCIDSource Title Sex Differences in Heart Disease. - Cham : Springer International Publishing, 2020 / Dhalla Naranjan S. ; Ošťádal Bohuslav - ISBN 978-3-030-58676-8 Pages s. 25-37 Number of pages 13 s. Number of pages 284 Publication form Print - P Language eng - English Country CH - Switzerland Keywords sex differences ; ischemia/reperfusion injury ; role of estrogen ; cardiac tolarance Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects GA18-03207S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 DOI 10.1007/978-3-030-58677-5_2 Annotation I tis now well known that differences in the structure and function of the heart exist between male and female hearts. Several lines of exerimental and clinical investigations have reported that there are sex differences in the tolerance to myocardial ischemia, whereby adult male hearts are more susceptible to ischemia/reperfusion (I/R) injury as compared to pre-menopausal female hearts. Experimental studies have also shown that adult female hearts have increased resistence and male hearts are more susceptible to I/R in animal exposed to perinatal hypoxia. Although there is now a large body of evidence which indicates that estrogen is involved in the sex differences with respect to cardiac tolerance to ischemia, the exact mechanisms involved in the cardiac response to ischemia or hypoxia are not fully understood. Accordingly, this chapter is intended to describe some of the known molecular nad cellular mechanisms that contribute to sex differences in the susceptibility to I/R injury. With such a new basic information and advancements in the understanding of the mechanisms responsible for sex differences in cardiac sensitivity to ischemic injury, it is hoped that some specific therapeutic strategies will be developed for post-menopausal females for better quality of life, and lower mortality. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://doi.org/10.1007/978-3-030-58677-5_2
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