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Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes
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SYSNO ASEP 0535546 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes Author(s) Kostiv, Uliana (UMCH-V) RID
Kučka, Jan (UMCH-V) RID, ORCID
Lobaz, Volodymyr (UMCH-V) RID, ORCID
Kotov, Nikolay (UMCH-V) RID, ORCID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Krajnik, B. (PL)
Podhorodecki, A. (PL)
Francová, P. (CZ)
Šefc, L. (CZ)
Jirák, D. (CZ)
Horák, Daniel (UMCH-V) RID, ORCIDArticle number 20016 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020), s. 1-14Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords upconversion ; magnetic ; PEG-neridronate Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA19-00676S GA ČR - Czech Science Foundation (CSF) GA18-07983S GA ČR - Czech Science Foundation (CSF) TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 8JPL19006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i. Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000595719100001 EID SCOPUS 85096206151 DOI https://doi.org/10.1038/s41598-020-77112-z Annotation All-in-one multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.nature.com/articles/s41598-020-77112-z
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