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Light‐activated carbon monoxide prodrugs based on bipyridyl dicarbonyl ruthenium(II) complexes
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SYSNO ASEP 0532238 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Light‐activated carbon monoxide prodrugs based on bipyridyl dicarbonyl ruthenium(II) complexes Author(s) Geri, S. (DE)
Krunclová, Tereza (UMCH-V) ORCID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Pánek, Jiří (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCID
Hernández-Valdés, D. (CH)
Probst, B. (CH)
Alberto, R. A. (CH)
Mamat, C. (DE)
Kubeil, M. (DE)
Stephan, H. (DE)Source Title Chemistry - A European Journal. - : Wiley - ISSN 0947-6539
Roč. 26, č. 48, SI (2020), s. 10992-11006Number of pages 15 s. Language eng - English Country DE - Germany Keywords carbon monoxide ; prodrug ; light activation Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA19-01438S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000563928800001 EID SCOPUS 85089397245 DOI 10.1002/chem.202002139 Annotation Two photoactivatable dicarbonyl ruthenium(II) complexes based on an amide‐functionalised bipyridine scaffold (4‐position) equipped with an alkyne functionality or a green‐fluorescent BODIPY (boron‐dipyrromethene) dye have been prepared and used to investigate their light‐induced decarbonylation. UV/Vis, FTIR and 13C NMR spectroscopies as well as gas chromatography and multivariate curve resolution alternating least‐squares analysis (MCR‐ALS) were used to elucidate the mechanism of the decarbonylation process. Release of the first CO molecule occurs very quickly, while release of the second CO molecule proceeds more slowly. In vitro studies using two cell lines A431 (human squamous carcinoma) and HEK293 (human embryonic kidney cells) have been carried out in order to characterise the anti‐proliferative and anti‐apoptotic activities. The BODIPY‐labelled compound allows for monitoring the cellular uptake, showing fast internalisation kinetics and accumulation at the endoplasmic reticulum and mitochondria. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202002139
Number of the records: 1