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Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins?
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SYSNO ASEP 0531466 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Overview of in vivo and ex vivo endpoints in murine food allergy models: Suitable for evaluation of the sensitizing capacity of novel proteins? Author(s) Castan, L. (FR)
Bogh, K.L. (DK)
Maryniak, N.Z. (DK)
Epstein, M.M. (AT)
Kazemi, S. (AT)
O'Mahony, L. (IE)
Bodinier, M. (FR)
Smit, J.J. (NL)
van Bilsen, J.H.M. (NL)
Blanchard, C. (GB)
Głogowski, R. (PL)
Kozáková, Hana (MBU-M) RID, ORCID
Schwarzer, Martin (MBU-M) ORCID, RID
Noti, M. (CH)
de Wit, N. (NL)
Bouchaud, G. (FR)
Bastiaan‐Net, S. (NL)Source Title Allergy. - : Wiley - ISSN 0105-4538
Roč. 75, č. 2 (2020), s. 289-301Number of pages 13 s. Language eng - English Country US - United States Keywords animal models ; biomarkers ; food allergy Subject RIV EE - Microbiology, Virology OECD category Microbiology Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000479528200001 EID SCOPUS 85074842503 DOI 10.1111/all.13943 Annotation Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically relevant allergic sensitization. With food allergy being a major health problem of increasing concern, understanding the potential allergenicity of new or modified proteins is crucial to ensure public health protection. The best predictive risk assessment methods currently relied on are in vivo models, making the choice of endpoint parameters a key element in evaluating the sensitizing capacity of novel proteins. Here, we provide a comprehensive overview of the most frequently used in vivo and ex vivo endpoints in murine food allergy models, addressing their strengths and limitations for assessing sensitization risks. For optimal laboratory-to-laboratory reproducibility and reliable use of predictive tests for protein risk assessment, it is important that researchers maintain and apply the same relevant parameters and procedures. Thus, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research in synergy between both knowledge institutes and clinicians. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2021 Electronic address https://d360prx.biomed.cas.cz:2630/doi/10.1111/all.13943
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