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Organization of gangliosides into membrane nanodomains
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SYSNO ASEP 0531042 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Organization of gangliosides into membrane nanodomains Author(s) Sarmento, Maria Joäo (UFCH-W) ORCID, RID
Ricardo, Joana Catarina (UFCH-W) ORCID, SAI, RID
Amaro, Mariana (UFCH-W) RID, ORCID
Šachl, Radek (UFCH-W) RID, ORCIDSource Title FEBS Letters. - : Wiley - ISSN 0014-5793
Roč. 594, č. 22 (2020), s. 3668-3697Number of pages 30 s. Language eng - English Country NL - Netherlands Keywords afm ; diffusion ; diffusion laws ; gangliosides ; gm 1 ; lipid bilayers ; mc-fret ; membrane model systems ; nanodomains ; phase separation Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GA18-04871S GA ČR - Czech Science Foundation (CSF) GC20-01401J GA ČR - Czech Science Foundation (CSF) EF16_027/0008355 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000546730400001 EID SCOPUS 85087739001 DOI 10.1002/1873-3468.13871 Annotation Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain that contains one or more sialic acids. This unique structure endows gangliosides with a strong tendency to self-aggregate in solution, as well as in cellular membranes, where they can form nanoscopic assemblies called ganglioside nanodomains. As gangliosides are important biological molecules involved in a number of physiological processes, characterization of their lateral organization in membranes is essential. This review aims at providing comprehensive information about the nanoscale organization of gangliosides in various synthetic models. To this end, the impact of the hydrophobic backbone and the headgroup on the segregation of gangliosides into nanodomains are discussed in detail, as well as the way in which the properties of nanodomains are affected by ligand binding. Small size makes the characterization of ganglioside nanodomains challenging, and we thus highlight the biophysical methods that have advanced this research, such as Monte Carlo Förster resonance energy transfer, atomic force microscopy and approaches based on molecular diffusion. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0309799
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