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Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications
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SYSNO ASEP 0525575 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications Author(s) Kirakci, Kaplan (UACH-T) SAI, RID, ORCID
Zelenka, J. (CZ)
Křížová, I. (CZ)
Ruml, T. (CZ)
Lang, Kamil (UACH-T) SAI, RID, ORCIDNumber of authors 5 Source Title Inorganic Chemistry. - : American Chemical Society - ISSN 0020-1669
Roč. 59, č. 13 (2020), s. 9287-9293Number of pages 7 s. Language eng - English Country US - United States Keywords Serum ; Luminescence ; Ligands ; Toxicity ; Irradiation Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry R&D Projects GA18-05076S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UACH-T - RVO:61388980 UT WOS 000548456300068 EID SCOPUS 85087531460 DOI 10.1021/acs.inorgchem.0c01173 Annotation Two new octahedral molybdenum cluster complexes act as an efficient singlet oxygen supplier in the context of the photodynamic therapy of cancer cells under blue-light irradiation. These complexes integrate the {Mo6I8}4+ core with 4'-carboxybenzo-15-crown-5 or cholate apical ligands and were characterized by 1H NMR, HR ESI-MS, and CHN elemental analysis. Both complexes display high quantum yields of luminescence and singlet oxygen formation in aqueous media associated with a suitable stability against hydrolysis. They are internalized into lysosomes of HeLa cells with no dark toxicity at pharmacologically relevant concentrations and have a strong phototoxic effect under blue-light irradiation, even in the presence of fetal bovine serum. The last feature is essential for further translation to in vivo experiments. Overall, these complexes are attractive molecular photosensitizers toward photodynamic applications. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2021 Electronic address https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c01173
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