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Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer
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SYSNO ASEP 0525185 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer Author(s) Marková, I. (CZ)
Koníčková, R. (CZ)
Vaňková, K. (CZ)
Leníček, M. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Strnad, Hynek (UMG-J) RID
Hradilová, Miluše (UMG-J)
Šáchová, Jana (UMG-J)
Rasl, Jan (MBU-M) ORCID
Klímová, Zuzana (MBU-M) RID
Vomastek, Tomáš (MBU-M) RID, ORCID
Němečková, I. (CZ)
Nachtigal, P. (CZ)
Vítek, L. (CZ)Number of authors 14 Source Title Journal of Cellular and Molecular Medicine. - : Wiley - ISSN 1582-1838
Roč. 24, č. 4 (2020), s. 2402-2415Number of pages 14 s. Publication form Online - E Language eng - English Country US - United States Keywords angiogenesis ; anticancer effects ; Arthrospira platensis ; carcinogenesis ; pancreatic cancer Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology Subject RIV - cooperation Institute of Microbiology - Biochemistry R&D Projects NV16-29032A GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support UMG-J - RVO:68378050 ; MBU-M - RVO:61388971 UT WOS 000507858400001 DOI 10.1111/jcmm.14922 Annotation Arthrospira platensis, a blue-green alga, is a popular nutraceutical substance having potent antioxidant properties with potential anti-carcinogenic activities. The aim of our study was to assess the possible anti-angiogenic effects of A platensis in an experimental model of pancreatic cancer. The effects of an A platensis extract were investigated on human pancreatic cancer cells (PA-TU-8902) and immortalized endothelial-like cells (Ea.hy926). PA-TU-8902 pancreatic tumours xenografted to athymic mice were also examined. In vitro migration and invasiveness assays were performed on the tested cells. Multiple angiogenic factors and signalling pathways were analysed in the epithelial, endothelial and cancer cells, and tumour tissue. The A platensis extract exerted inhibitory effects on both migration and invasion of pancreatic cancer as well as endothelial-like cells. Tumours of mice treated with A platensis exhibited much lesser degrees of vascularization as measured by CD31 immunostaining (P = .004). Surprisingly, the VEGF-A mRNA and protein expressions were up-regulated in pancreatic cancer cells. A platensis inhibited ERK activation upstream of Raf and suppressed the expression of ERK-regulated proteins. Treatment of pancreatic cancer with A platensis was associated with suppressive effects on migration and invasiveness with various anti-angiogenic features, which might account for the anticancer effects of this blue-green alga. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2021 Electronic address https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.14922
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