The biocompatibility of polyaniline and polypyrrole 2.sup.1./sup.: doping with organic phosphonates

Capáková, Z.; Radaszkiewicz, K. A.; Acharya, Udit; Truong, T. H.; Pacherník, J.; Bober, Patrycja; Kašpárková, V.; Stejskal, Jaroslav; Pfleger, Jiří; Lehocký, M.; Humpolíček, P.

doi:https://dx.doi.org/10.1016/j.msec.2020.110986

Number of the records: 1

The biocompatibility of polyaniline and polypyrrole 2.sup.1./sup.: doping with organic phosphonates

1.

SYSNO ASEP	0524189
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The biocompatibility of polyaniline and polypyrrole 2¹: doping with organic phosphonates
Author(s)	Capáková, Z. (CZ) Radaszkiewicz, K. A. (CZ) Acharya, Udit (UMCH-V)_{RID, ORCID} Truong, T. H. (CZ) Pacherník, J. (CZ) Bober, Patrycja (UMCH-V)_{RID, ORCID, SAI} Kašpárková, V. (CZ) Stejskal, Jaroslav (UMCH-V)_{RID, ORCID, SAI} Pfleger, Jiří (UMCH-V)_RID Lehocký, M. (CZ) Humpolíček, P. (CZ)
Article number	110986
Source Title	Materials Science & Engineering C-Materials for Biological Applications. - : Elsevier - ISSN 0928-4931 Roč. 113, August (2020), s. 1-8
Number of pages	8 s.
Language	eng - English
Country	NL - Netherlands
Keywords	polyaniline ; polypyrrole ; conducting polymers biocompatibility
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000537712500041
EID SCOPUS	85084173779
DOI	10.1016/j.msec.2020.110986
Annotation	Conducting polymers (CP) can be used as pH- and/or electro-responsive components in various bioapplications, for example, in 4D smart scaffolds. The ability of CP to maintain conductivity under physiological conditions is, therefore, their crucial property. Unfortunately, the conductivity of the CP rapidly decreases in physiological environment, as their conducting salts convert to non-conducting bases. One of the promising solutions how to cope with this shortcoming is the use of alternative “doping” process that is not based on the protonation of CP with acids but on interactions relying in acidic hydrogen bonding. Therefore, the phosphonates (dimethyl phosphonate, diethyl phosphonate, dibutyl phosphonate, or diphenyl phosphonate) were used to re-dope two most common representatives of CP, polyaniline (PANI) and polypyrrole (PPy) bases. As a result, PANI doped with organic phosphonates proved to have significantly better stability of conductivity under different pH. It has also been shown that cytotoxicity of studied materials determined on embryonic stem cells and their embryotoxicity, determined as the impact on cardiomyogenesis and erythropoiesis, depend both on the polymer and phosphonate types used. With the exception of PANI doped with dibutyl phosphonate, all PPy-based phosphonates showed better biocompatibility than the phosphonates based on PANI.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/pii/S0928493120301892?via%3Dihub

Number of the records: 1