Number of the records: 1
Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae
- 1.
SYSNO ASEP 0523977 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae Author(s) Cutova, M. (CZ)
Manta, J. (CZ)
Porubiakova, O. (CZ)
Kaura, P. (CZ)
Šťastný, J. (CZ)
Jagelská, Eva (BFU-R)
Goswami, Pratik (BFU-R)
Bartas, M. (CZ)
Brázda, Václav (BFU-R) RID, ORCIDNumber of authors 9 Source Title Genomics. - : Elsevier - ISSN 0888-7543
Roč. 112, č. 2 (2020), s. 1897-1901Number of pages 5 s. Publication form Print - P Language eng - English Country US - United States Keywords web-based server ; nucleic-acids ; dna ; binding ; transcription Subject RIV EB - Genetics ; Molecular Biology OECD category Genetics and heredity (medical genetics to be 3) R&D Projects GA18-15548S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000514071600093 EID SCOPUS 85075470548 DOI 10.1016/j.ygeno.2019.11.002 Annotation The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0888754319305269?via%3Dihub
Number of the records: 1