Number of the records: 1
Thermoplastic starch composites with titanium dioxide and vancomycin antibiotic: preparation, morphology, thermomechanical properties, and antimicrobial susceptibility testing
- 1.
SYSNO ASEP 0521495 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Thermoplastic starch composites with titanium dioxide and vancomycin antibiotic: preparation, morphology, thermomechanical properties, and antimicrobial susceptibility testing Author(s) Ujčić, Aleksanda (UMCH-V) RID, ORCID
Krejčíková, Sabina (UMCH-V)
Nevoralová, Martina (UMCH-V) RID, ORCID
Zhigunov, Alexander (UMCH-V) RID, ORCID
Dybal, Jiří (UMCH-V) RID, ORCID
Kruliš, Zdeněk (UMCH-V) RID, ORCID
Fulín, P. (CZ)
Nyč, O. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCIDArticle number 9 Source Title Frontiers in Materials. - : Frontiers Media - ISSN 2296-8016
Roč. 7, January (2020), s. 1-13Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords thermoplastic starch ; morphology ; thermomechanical properties Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects NV15-31269A GA MZd - Ministry of Health (MZ) TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) TN01000008 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000514905800001 EID SCOPUS 85079497643 DOI 10.3389/fmats.2020.00009 Annotation Biodegradable composites of thermoplastic starch (TPS), titanium dioxide particles (TiO2, average size 0.2 μm), and/or antibiotic (ATB, vancomycin) were prepared. Light and electron microscopy demonstrated that our recently developed, two-step preparation procedure yielded highly homogeneous TPS matrix with well-dispersed TiO2 particles even for high filler concentrations (up to 20%). Oscillatory shear rheometry showed an increase in viscosity of TPS after addition of TiO2 and ATB (from ca 2 × 105 Pa·s to ca 1 × 106 Pa·s at 1 rad/s and 120°C). However, the high viscosity of TPS/TiO2/ATB composites did not prevent reproducible preparation of the composites by melt-mixing. Dynamic mechanical analysis proved a significant increase in shear moduli (storage, loss and complex modulus) of TPS after addition of TiO2 and ATB (storage modulus increased from ca 25 MPa to more than 600 MPa at 1.33 rad/s at room temperature). Both rheological and mechanical properties indicated strong interactions among TPS matrix, filler, and antibiotics. The final TPS composites were soft enough to be cut with a sharp blade at room temperature, the TPS matrix was fully biodegradable, the TiO2 filler was biocompatible, and the ATB could be released locally during the matrix degradation. Selected samples were tested for bacterial susceptibility using standard tube dilution test and disk diffusion test. The results proved that the ATB retained its bacteriostatic properties after the thermal processing of the composites. Therefore, the prepared TPS/TiO2/ATB composites represent a promising material for biomedical applications related to the local release of antibiotics. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.frontiersin.org/articles/10.3389/fmats.2020.00009/full
Number of the records: 1