Number of the records: 1  

Laser irradiation induces mitochondrial dysfunction in hepatic cells

  1. 1.
    SYSNO ASEP0521405
    Document TypeC - Proceedings Paper (int. conf.)
    R&D Document TypeConference Paper
    TitleLaser irradiation induces mitochondrial dysfunction in hepatic cells
    Author(s) Lynnyková, Anna (FZU-D) RID
    Smolková, Barbora (FZU-D) ORCID
    Uzhytchak, Mariia (FZU-D) ORCID
    Egorova, D. (RU)
    Kulikov, A. (RU)
    Lunova, Mariia (FZU-D) ORCID
    Kubinová, Šárka (UEM-P) RID, ORCID
    Dejneka, Alexandr (FZU-D) RID, ORCID
    Lunov, Oleg (FZU-D) ORCID
    Number of authors9
    Article number1107911
    Source TitleMedical Laser Applications and Laser-Tissue Interactions IX. - Bellingham : SPIE, 2019 / Lilge L.D. ; Philipp C.M. - ISSN 0277-786X - ISBN 978-151062851-9
    Pagess. 1-4
    Number of pages4 s.
    Publication formPrint - P
    ActionMedical Laser Applications and Laser-Tissue Interactions IX 2019
    Event date23.06.2019 - 24.06.2019
    VEvent locationMunich
    CountryDE - Germany
    Event typeWRD
    Languageeng - English
    CountryUS - United States
    Keywordslaser irradiation ; hepatic cells ; cell death ; mitochondrial dysfunction
    Subject RIVBO - Biophysics
    OECD categoryBiophysics
    Subject RIV - cooperationInstitute of Experimental Medicine - Biophysics
    Institutional supportFZU-D - RVO:68378271 ; UEM-P - RVO:68378041
    EID SCOPUS85074248408
    DOI10.1117/12.2527110
    AnnotationLaser irradiation has been recognized as a promising tool across a number of biomedical applications. However, understanding the molecular mechanisms and cellular responses remains incomplete. Here, we investigated the mechanism involved in the apoptotic process in human hepatic cells under laser irradiation. Our data show that the laser-mediated alternation of mitochondrial membrane potential leads apoptosis in Huh7 and Alexander cells. Contrary, HepG2 cells are resistant to laser induced cell death. The observed link between mitochondrial membrane potential and cytotoxicity could be a fundamental phenomenon in laser-induced cell apoptosis.
    WorkplaceInstitute of Physics
    ContactKristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
    Year of Publishing2020
Number of the records: 1  

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