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Laser irradiation induces mitochondrial dysfunction in hepatic cells
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SYSNO ASEP 0521405 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Laser irradiation induces mitochondrial dysfunction in hepatic cells Author(s) Lynnyková, Anna (FZU-D) RID
Smolková, Barbora (FZU-D) ORCID
Uzhytchak, Mariia (FZU-D) ORCID
Egorova, D. (RU)
Kulikov, A. (RU)
Lunova, Mariia (FZU-D) ORCID
Kubinová, Šárka (UEM-P) RID, ORCID
Dejneka, Alexandr (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCIDNumber of authors 9 Article number 1107911 Source Title Medical Laser Applications and Laser-Tissue Interactions IX. - Bellingham : SPIE, 2019 / Lilge L.D. ; Philipp C.M. - ISSN 0277-786X - ISBN 978-151062851-9 Pages s. 1-4 Number of pages 4 s. Publication form Print - P Action Medical Laser Applications and Laser-Tissue Interactions IX 2019 Event date 23.06.2019 - 24.06.2019 VEvent location Munich Country DE - Germany Event type WRD Language eng - English Country US - United States Keywords laser irradiation ; hepatic cells ; cell death ; mitochondrial dysfunction Subject RIV BO - Biophysics OECD category Biophysics Subject RIV - cooperation Institute of Experimental Medicine - Biophysics Institutional support FZU-D - RVO:68378271 ; UEM-P - RVO:68378041 EID SCOPUS 85074248408 DOI 10.1117/12.2527110 Annotation Laser irradiation has been recognized as a promising tool across a number of biomedical applications. However, understanding the molecular mechanisms and cellular responses remains incomplete. Here, we investigated the mechanism involved in the apoptotic process in human hepatic cells under laser irradiation. Our data show that the laser-mediated alternation of mitochondrial membrane potential leads apoptosis in Huh7 and Alexander cells. Contrary, HepG2 cells are resistant to laser induced cell death. The observed link between mitochondrial membrane potential and cytotoxicity could be a fundamental phenomenon in laser-induced cell apoptosis.
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2020
Number of the records: 1