Number of the records: 1
Use of RLI-15 a clinical grade fusion protein with IL-15 superagonistic activity for the activation of anti-tumor immune response
- 1.
SYSNO ASEP 0521311 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Use of RLI-15 a clinical grade fusion protein with IL-15 superagonistic activity for the activation of anti-tumor immune response Author(s) Adkins, I. (CZ)
Sadílková, I. (CZ)
Hradilová, N. (CZ)
Tomala, Jakub (MBU-M) RID, ORCID
Tomalová, Barbora (MBU-M) ORCID
Kovář, Marek (MBU-M) RID, ORCID
Mikysková, R. (CZ)
Reiniš, Milan (UMG-J) RID
de Martynoff, G. (FR)
Bechard, D. (FR)
Moebius, U. (CZ)
Spíšek, R. (CZ)Source Title Cancer Research. - : American Association for Cancer Research - ISSN 0008-5472
Roč. 78, 13 S (2018)Number of pages 3 s. Publication form Print - P Action Annual Meeting of the American-Association-for-Cancer-Research (AACR) Event date 14.04.2018 - 18.04.2018 Country US - United States Event type WRD Language eng - English Country US - United States Keywords RLI-15 ; IL-15 ; carcinoma Subject RIV EE - Microbiology, Virology OECD category Microbiology Institutional support MBU-M - RVO:61388971 UT WOS 000468819502035 DOI 10.1158/1538-7445.AM2018-3775 Annotation RLI-15, a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain represents a promising candidate for the induction of anti-tumor immunity. RLI-15 was designed to bypass the need of endogenous IL-15Rα, thereby leveraging the activity of IL-15 in vivo on target immune cells. RLI-15 stimulates the proliferation and the cytotoxic activity of natural killer (NK) cells and memory CD8+ T cells with no significant expansion and activation of regulatory T cell compartment. RLI-15 was previously shown to exhibit a potent anti-metastatic activity in B16F10 melanoma and Renca renal cell carcinoma mouse models. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2020
Number of the records: 1