Mitochondria-driven elimination of cancer and senescent cells

0520732 - BTÚ 2020 RIV DE eng J - Journal Article
Hubáčková, Soňa - Novais, Silvia Magalhaes - Davidová, Eliška - Neužil, Jiří - Rohlena, Jakub
Mitochondria-driven elimination of cancer and senescent cells.
Biological Chemistry. Roč. 400, č. 2 (2019), s. 141-148. ISSN 1431-6730. E-ISSN 1437-4315
R&D Projects: GA ČR GA17-20904S; GA ČR GA16-22823S; GA ČR(CZ) GA18-02550S; GA ČR(CZ) GC17-01192J; GA ČR GA16-12719S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : cellular senescence * oxidative stress * contributes * suppression * respiration
OECD category: Biochemistry and molecular biology
Impact factor: 3.270, year: 2019
Method of publishing: Open access
https://www.nature.com/articles/s41418-018-0118-3

Mitochondria and oxidative phosphorylation (OXPHOS) are emerging as intriguing targets for the efficient elimination of cancer cells. The specificity of this approach is aided by the capacity of non-proliferating non-cancerous cells to withstand oxidative insult induced by OXPHOS inhibition. Recently we discovered that mitochondrial targeting can also be employed to eliminate senescent cells, where it breaks the interplay between OXPHOS and ATP transporters that appear important for the maintenance of mitochondrial morphology and viability in the senescent setting. Hence, mitochondria/OXPHOS directed pharmacological interventions show promise in several clinically-relevant scenarios that call for selective removal of cancer and senescent cells.
Permanent Link: http://hdl.handle.net/11104/0305579