Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof

0519574 - ÚOCHB 2020 RIV eng P - Patent Document
Jansa, Petr - Holý, Antonín - Zídek, Zdeněk - Kmoníčková, Eva - Janeba, Zlatko
Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof.
2019. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav experimentální medicíny AV ČR, v. v. i. Date of the patent acceptance: 04.09.2019. Patent Number: EP3195867
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine compounds * prostaglandin E2 * nitric oxide
OECD category: Organic chemistry; Pharmacology and pharmacy (UEM-P)
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20190904&DB=&locale=en_EP&CC=EP&NR=3195867B1&KC=B1&ND=4#

The invention provides pyrimidine compounds of general formula (I), which reduce simultaneously the production of nitric oxide (NO) and prostaglandin E2 (PGE2). They have no negative effect on the viability of cells in concentrations decreasing the production of these factors by up to 50%, they are not cytotoxic. Furthermore, a method of preparation of the pyrimidine compounds of general formula (I), carrying 2-formamido group, a pharmaceutical composition comprising the substituted pyrimidine compounds according to the invention, and the use of these compounds for the treatment of inflammatory and cancer diseases are provided.
Permanent Link: http://hdl.handle.net/11104/0304712