Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

Lind, A. L.; Lai, Y. Y.; Mostovoy, Y.; Holloway, A. K.; Iannucci, A.; Mak, A. C. Y.; Fondi, M.; Orlandini, V.; Eckalbar, W. L.; Milan, M.; Rovatsos, Michail; Kichigin, I. G.; Makunin, A. I.; Johnson Pokorná, Martina; Altmanová, Marie; Trifonov, V. A.; Schijlen, E.; Kratochvíl, L.; Fani, R.; Velenský, P.; Řehák, I.; Patarnello, T.; Jessop, T. S.; Hicks, J. W.; Ryder, O.; Mendelson, J. R.; Ciofi, C.; Kwok, P.Y.; Pollard, K. S.; Bruneau, B. G.

doi:https://dx.doi.org/10.1038/s41559-019-0945-8

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Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards

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SYSNO ASEP	0512006
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards
Author(s)	Lind, A. L. (US) Lai, Y. Y. (US) Mostovoy, Y. (US) Holloway, A. K. (US) Iannucci, A. (IT) Mak, A. C. Y. (US) Fondi, M. (IT) Orlandini, V. (IT) Eckalbar, W. L. (US) Milan, M. (IT) Rovatsos, Michail (UZFG-Y)_ORCID Kichigin, I. G. (RU) Makunin, A. I. (RU) Johnson Pokorná, Martina (UZFG-Y)_ORCID Altmanová, Marie (UZFG-Y)_ORCID Trifonov, V. A. (RU) Schijlen, E. (NL) Kratochvíl, L. (CZ) Fani, R. (IT) Velenský, P. (CZ) Řehák, I. (CZ) Patarnello, T. (IT) Jessop, T. S. (AU) Hicks, J. W. (US) Ryder, O. (US) Mendelson, J. R. (US) Ciofi, C. (IT) Kwok, P.Y. (US) Pollard, K. S. (US) Bruneau, B. G. (US)
Source Title	Nature Ecology & Evolution. - : Nature Portfolio - ISSN 2397-334X Roč. 3, č. 8 (2019), s. 1241-1252
Number of pages	12 s.
Publication form	Print - P
Language	eng - English
Country	GB - United Kingdom
Keywords	Komodo dragon ; monitor lizards
Subject RIV	EB - Genetics ; Molecular Biology
OECD category	Genetics and heredity (medical genetics to be 3)
Method of publishing	Open access
Institutional support	UZFG-Y - RVO:67985904
UT WOS	000477903700018
EID SCOPUS	85069907719
DOI	https://doi.org/10.1038/s41559-019-0945-8
Annotation	Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2020
Electronic address	https://www.nature.com/articles/s41559-019-0945-8

Number of the records: 1