Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

0510302 - ÚEB 2020 RIV US eng J - Journal Article
Záveský, L. - Jandáková, E. - Weinberger, V. - Minář, L. - Hanzíková, V. - Dušková, D. - Záveská Drábková, Lenka - Hořínek, A.
Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers.
Cancer Investigation. Roč. 37, č. 9 (2019), s. 440-452. ISSN 0735-7907. E-ISSN 1532-4192
Institutional support: RVO:61389030
Keywords : ascites * effusion * microRNA * Ovarian cancer * tumor
OECD category: Oncology
Impact factor: 2.398, year: 2019
Method of publishing: Open access
http://dx.doi.org/10.1080/07357907.2019.1663208

Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
Permanent Link: http://hdl.handle.net/11104/0300814