SET‐LRP synthesis of well‐defined light‐responsible block copolymer micelles

0509157 - ÚMCH 2020 RIV DE eng J - Journal Article
Sedláček, Ondřej - Filippov, Sergey K. - Švec, Pavel - Hrubý, Martin
SET‐LRP synthesis of well‐defined light‐responsible block copolymer micelles.
Macromolecular Chemistry and Physics. Roč. 220, č. 19 (2019), s. 1-7, č. článku 1900238. ISSN 1022-1352. E-ISSN 1521-3935
R&D Projects: GA MŠMT(CZ) LM2015064; GA ČR(CZ) GA18-07983S
Grant - others:AV ČR(CZ) FWO-19-03
Program: Bilaterální spolupráce
Institutional support: RVO:61389013
Keywords : micelles * UV-degradation * controlled radical polymerization
OECD category: Polymer science
Impact factor: 2.335, year: 2019
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/full/10.1002/macp.201900238

Herein, the synthesis of well‐defined light‐sensitive amphiphilic diblock copolymers consisting of UV‐responsive poly(2‐nitrobenzyl acrylate) (PNBA) and hydrophilic poly(ethylene oxide) (PEO) blocks is reported. This is achieved by a single electron transfer living radical polymerization (SET‐LRP) of 2‐nitrobenzyl acrylate monomer initiated by PEO‐containing macroinitiator. Despite several reports on PEO‐b‐PNBA copolymers, this is the first time the PNBA block is synthesized by a controlled radical polymerization leading to the copolymers with low dispersity (Ð = 1.10). In water, the copolymers self‐assemble into well‐defined micelles with a hydrodynamic diameter of 25 nm. Upon irradiation with UV‐light, the PNBA units degrade to hydrophilic poly(acrylate) resulting in disassembly of the micelles. Considering the robustness of the reported synthetic protocol, the prepared polymers represent an interesting platform for the construction of new stimuli‐responsive drug delivery systems.
Permanent Link: http://hdl.handle.net/11104/0300606