A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer

0509156 - FGÚ 2020 RIV CH eng J - Journal Article
Kopová, Ivana - Kronek, J. - Bačáková, Lucie - Fencl, J.
A cytotoxicity and wear analysis of trapeziometacarpal total joint replacement implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer.
Diamond and Related Materials. Roč. 97, Aug (2019), č. článku UNSP 107456. ISSN 0925-9635. E-ISSN 1879-0062
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823
Keywords : simulated loading * Ti gradient interlayer * wear debris * cell proliferation * xCELLigence
OECD category: Biomaterials (as related to medical implants, devices, sensors)
Impact factor: 2.650, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.diamond.2019.107456

Diamond-like carbon (DLC) coatings exhibit excellent mechanical properties and improve the smoothness and the wear characteristic of the metallic component of total joint replacements. Although DLC is considered to be highly biocompatible, the effect of implant wear debris must be carefully analyzed. Simulated loading can help to mimic the wear of the implant in the human body over time. The purpose of the study presented here is to observe the wear of trapeziometacarpal (TMC) total joint arthroplasty implant consisting of DLC-coated Co-Cr-Mo alloy with the use of titanium gradient interlayer (Ti/Ti-C:H), and to analyze the potential cytotoxicity of the wear particles generated by simulated loading. No visible wear or delamination of the DLC coating was observed after 3 million cycles of increasing loading force up to 2.5 kN. Accordingly, no correlation was observed between increasing number of loading cycles (with increasing loading force) and decreasing proliferation of human osteoblast-like cells incubated in the wear suspension. We can therefore conclude that no cytotoxic wear debris was formed during the simulated loading of TMC total joint replacement implant composed of DLC-coated Co-Cr-Mo alloy with Ti/Ti-C:H gradient interlayer.
Permanent Link: http://hdl.handle.net/11104/0299924