Number of the records: 1
Synthesis of Cyclic and Acyclic Nucleoside Phosphonates and Sulfonamides Derived from 6‐(Thiophen‐2‐yl)‐7‐fluoro‐7‐deazapurine
- 1.
SYSNO ASEP 0509096 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of Cyclic and Acyclic Nucleoside Phosphonates and Sulfonamides Derived from 6‐(Thiophen‐2‐yl)‐7‐fluoro‐7‐deazapurine Author(s) Malnuit, Vincent (UOCHB-X)
Smolen, Sabina (UOCHB-X)
Tichý, Michal (UOCHB-X) RID, ORCID
Poštová Slavětínská, Lenka (UOCHB-X) RID
Hocek, Michal (UOCHB-X) RID, ORCIDSource Title European Journal of Organic Chemistry - ISSN 1434-193X
Roč. 2019, 31/32 (2019), s. 5409-5423Number of pages 15 s. Language eng - English Country DE - Germany Keywords 7‐deazapurine ; nucleoside phosphonates ; structure‐activity relationships ; synthetic methods ; sulfonamides Subject RIV CC - Organic Chemistry OECD category Organic chemistry R&D Projects GA19-08124S GA ČR - Czech Science Foundation (CSF) NV15-31984A GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support UOCHB-X - RVO:61388963 UT WOS 000483709700045 EID SCOPUS 85071312015 DOI 10.1002/ejoc.201900509 Annotation Ribonuclosides derived from 6-hetaryl-7-dezapurines are potent cytostatics, but their mechanism of action is unknown. Here we designed and synthesized a series of cyclic and acyclic nucleoside phosphonates, as well as carboxy, cyano, sulfo, and sulfonamide acyclic analogues derived from 6-thiophen-2-yl-7-deazapurine and 7-fluoro-6-thiophen-2-yl-7-deazapurine as ribonucleoside monophosphate mimics. None of these analogues exerted significant cytotoxic and antiviral activity. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2020 Electronic address https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.201900509
Number of the records: 1