Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms

0507546 - FGÚ 2020 RIV US eng J - Journal Article
Krajčovič, Branislav - Fajnerová, Iveta - Horáček, J. - Kelemen, E. - Kubík, Štěpán - Svoboda, Jan - Stuchlík, Aleš
Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms.
Acta Physiologica. Roč. 226, č. 4 (2019), č. článku e13282. ISSN 1748-1708. E-ISSN 1748-1716
R&D Projects: GA ČR(CZ) GA17-04047S; GA MZd NV17-30833A; GA ČR(CZ) GA16-13399S
Institutional support: RVO:67985823
Keywords : fMRI * GABA interneurons * humans * oscillations * psychosis * rats
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.542, year: 2019
Method of publishing: Limited access
https://doi.org/10.1111/apha.13282

Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large‐scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive‐behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes.
Permanent Link: http://hdl.handle.net/11104/0298522