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Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines
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SYSNO ASEP 0506504 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines Author(s) Martincová, Iva (UBO-W) ORCID
Ďureje, Ľudovít (UBO-W) RID, SAI, SAI
Kreisinger, J. (CZ)
Macholán, Miloš (UZFG-Y) RID, ORCID
Piálek, Jaroslav (UBO-W) RID, ORCID, SAINumber of authors 5 Source Title Ecology and Evolution. - : Wiley - ISSN 2045-7758
Roč. 9, č. 10 (2019), s. 6124-6137Number of pages 14 s. Language eng - English Country US - United States Keywords Mus musculus domesticus ; Mus musculus musculus ; phenotype variation ; sperm quality ; wild-derived strain ; Y-associated effects Subject RIV EH - Ecology, Behaviour OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology Subject RIV - cooperation Institute of Animal Physiology and Genetics - Genetics ; Molecular Biology R&D Projects GA15-13265S GA ČR - Czech Science Foundation (CSF) GA17-25320S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UBO-W - RVO:68081766 ; UZFG-Y - RVO:67985904 UT WOS 000470923500046 EID SCOPUS 85066292228 DOI 10.1002/ece3.5196 Annotation Hybrid zones between divergent populations sieve genomes into blocks that introgress across the zone, and blocks that do not, depending on selection between interacting genes. Consistent with Haldane's rule, the Y chromosome has been considered counterselected and hence not to introgress across the European house mouse hybrid zone. However, recent studies detected massive invasion of M. m. musculus Y chromosomes into M. m. domesticus territory. To understand mechanisms facilitating Y spread, we created 31 recombinant lines from eight wild-derived strains representing four localities within the two mouse subspecies. These lines were reciprocally crossed and resulting F1 hybrid males scored for five phenotypic traits associated with male fitness. Molecular analyses of 51 Y-linked SNPs attributed 50% of genetic variation to differences between the subspecies and 8% to differentiation within both taxa. A striking proportion, 21% (frequencies of sperm head abnormalities) and 42% (frequencies of sperm tail dissociations), of phenotypic variation was explained by geographic Y chromosome variants. Our crossing design allowed this explanatory power to be examined across a hierarchical scale from subspecific to local intrastrain effects. We found that divergence and variation were expressed diversely in different phenotypic traits and varied across the whole hierarchical scale. This finding adds another dimension of complexity to studies of Y introgression not only across the house mouse hybrid zone but potentially also in other contact zones. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2020 Electronic address http://dx.doi.org/10.1002/ece3.5196
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