Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

0503157 - BTÚ 2019 RIV eng P - Patent Document
Neužil, Jiří - Werner, L. - Štursa, J.
Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level.
2018. Owner: J. Neužil, Biotechnologický ústav AV ČR, v. v. i., Smart Brain s.r.o., KKCG AG. Date of the patent acceptance: 26.03.2018. Patent Number: UA116469
Institutional support: RVO:86652036
Keywords : Mitochondrial targeting * Anticancer * Respiration
OECD category: Biochemistry and molecular biology
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The subject of the invention are new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivatives
of tamoxifen where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixture
(MitoTAX). Alkyl triphenylphosphonium derivatives oftamoxifen have the general formula (I), where n=8 to 12 and where Z is selected
from the group of organic salts or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the general
formula IA, where n = 6 to l 0 and where Z has the above mentioned meaning. These compounds are applicable for the treatment of
neoplastic disease, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases according to the
invention contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I)
and/or IA or their corresponding salts of tertiary amine.
Permanent Link: http://hdl.handle.net/11104/0294972