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HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart
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SYSNO ASEP 0503021 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart Author(s) Čerychová, Radka (BTO-N)
Pavlínková, Gabriela (BTO-N) RID, ORCIDNumber of authors 2 Article number 460 Source Title Frontiers in Endocrinology. - : Frontiers Media - ISSN 1664-2392
Roč. 9, AUG 15 2018 (2018)Number of pages 14 s. Language eng - English Country CH - Switzerland Keywords hypoxia-inducible factor 1 ; embryopathy ; cardiomyopathy Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition OECD category Endocrinology and metabolism (including diabetes, hormones) R&D Projects GA16-06825S GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BTO-N - RVO:86652036 UT WOS 000441562300001 EID SCOPUS 85052209773 DOI 10.3389/fendo.2018.00460 Annotation The heart is able to metabolize any substrate, depending on its availability, to satisfy its energy requirements. Under normal physiological conditions, about 95% of ATP is produced by oxidative phosphorylation and the rest by glycolysis. Cardiac metabolism undergoes reprograming in response to a variety of physiological and pathophysiological conditions. Hypoxia-inducible factor 1 (HIF-1) mediates the metabolic adaptation to hypoxia and ischemia, including the transition from oxidative to glycolytic metabolism. During embryonic development, HIF-1 protects the embryo from intrauterine hypoxia, its deletion as well as its forced expression are embryonically lethal. A decrease in HIF-1 activity is crucial during perinatal remodeling when the heart switches from anaerobic to aerobic metabolism. In the adult heart, HIF-1 protects against hypoxia, although its deletion in cardiomyocytes affects heart function even under normoxic conditions. Diabetes impairs HIF-1 activation and thus, compromises HIF-1 mediated responses under oxygen-limited conditions. Compromised HIF-1 signaling may contribute to the teratogenicity of maternal diabetes and diabetic cardiomyopathy in adults. In this review, we discuss the function of HIF-1 in the heart throughout development into adulthood, as well as the deregulation of HIF-1 signaling in diabetes and its effects on the embryonic and adult heart. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2019
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