Phospholipids and inositol phosphates linked to the epigenome

0499391 - ÚMG 2019 RIV US eng J - Journal Article
Uličná, Lívia - Paprčková, Darina - Fáberová, Veronika - Hozák, Pavel
Phospholipids and inositol phosphates linked to the epigenome.
Histochemistry and Cell Biology. Roč. 150, č. 3 (2018), s. 245-253. ISSN 0948-6143. E-ISSN 1432-119X
R&D Projects: GA ČR GA15-08738S; GA ČR(CZ) GA16-03346S; GA ČR(CZ) GA17-09103S; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775
Grant - others:GA MŠk(CZ) CZ.1.05/1.1.00/02.0109; AV ČR(CZ) JSPS-18-18
Program: Bilaterální spolupráce
Institutional support: RVO:68378050
Keywords : Phospholipids * Phosphoinositide * Inositol phosphate * Acetylation * Methylation
OECD category: Cell biology
Impact factor: 2.640, year: 2018

Even though the majority of knowledge about phospholipids comes from their cytoplasmic functions, in the last decade, it has been shown that nuclear phospholipids and their building blocks, inositol phosphates, have many important roles in the cell nucleus. There are clear connections of phospholipids with the regulation of gene expression and chromatin biology, however, this review focuses on less known functions of nuclear phospholipids in connection with the epigenome regulation. In particular, we highlight the roles of nuclear phospholipids and inositol phosphates that involve histone modifications, such as acetylation or methylation, tightly connected with the cell physiology. This demonstrates the importance of nuclear phospholipids in the regulation of cellular processes, and should encourage further research of nuclear phospholipids and inositol phosphates.
Permanent Link: http://hdl.handle.net/11104/0291631