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Rapid fabrication of microextraction devices for direct determination of basic drugs in dried blood spots
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SYSNO ASEP 0499020 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Rapid fabrication of microextraction devices for direct determination of basic drugs in dried blood spots Author(s) Ryšavá, Lenka (UIACH-O) RID, ORCID, SAI
Přikryl, Jan (UIACH-O) RID, ORCID
Dvořák, Miloš (UIACH-O)
Malá, Zdeňka (UIACH-O) RID
Kubáň, Pavel (UIACH-O) RID, ORCIDNumber of authors 5 Source Title CECE 2018. 15th International Interdisciplinary Meeting on Bioanalysis. - Brno : Ústav analytické chemie AV ČR, v. v. i., 2018 / Foret F. ; Křenková J. ; Drobníková I. ; Klepárník K. ; Přikryl J. - ISBN 978-80-904959-5-1 Pages s. 257-260 Number of pages 4 s. Publication form Online - E Action CECE 2018. International Interdisciplinary Meeting on Bioanalysis /15./ Event date 15.10.2018 - 17.10.2018 VEvent location Brno Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords supported liquid membrane (SLM) ; capillary electrophoresis ; microextraction devices Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry R&D Projects GA18-13135S GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 Annotation A 3D-printed cutter was designed for rapid fabrication of supported liquid membrane (SLM) extraction devices compatible with injection system of commercial capillary electrophoresis (CE) instrument. Low cost and single use microextraction devices were fabricated from polypropylene micropipette tips with high precision (dimension variances ≤ 3% RSD). Practical applicability of the microextraction devices was examined by in-line coupling of SLM extractions to CE for direct analysis of four model basic drugs in dried blood spot extracts. Excellent repeatability of the hyphenated technique was achieved (RSD ≤ 7.6%), transfer of analytes across the SLM ranged from 23 to 73% and limits of detection were as low as 0.07 μg/mL. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2019 Electronic address http://www.ce-ce.org/user_uploads/program/CECE%202018%20Proceedings_WOS.pdf
Number of the records: 1