Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified .gamma.-Fe2O3 nanoparticles towards human tumor cells

0493713 - ÚMCH 2019 RIV DE eng J - Journal Article
Plichta, Zdeněk - Kozak, Y. - Panchuk, R. - Sokolova, V. - Epple, M. - Kobylinska, L. - Jendelová, Pavla - Horák, Daniel
Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified .gamma.-Fe2O3 nanoparticles towards human tumor cells.
Beilstein Journal of Nanotechnology. Roč. 9, 25 Sep (2018), s. 2533-2545. ISSN 2190-4286. E-ISSN 2190-4286
R&D Projects: GA ČR(CZ) GA17-04918S
Institutional support: RVO:61389013 ; RVO:68378041
Keywords : magnetic * nanoparticles * poly[N-(2-hydroxypropyl)methacrylamide]
OECD category: Polymer science; Neurosciences (including psychophysiology (UEM-P)
Impact factor: 2.269, year: 2018

Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal stability in aqueous media and limited internalization by the cells, however, enabled adhesion to the cell surface. While the neat PHPMA-coated particles proved to be non-toxic, doxorubicin-conjugated particles exhibited enhanced cytotoxicity in both drug-sensitive and drug-resistant tumor cells compared to free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery.
Permanent Link: http://hdl.handle.net/11104/0287559