Magnetic oxide particles with gold nanoshells: synthesis, properties and cytotoxic effects

0493346 - FZÚ 2019 RIV NL eng J - Journal Article
Koktan, Jakub - Královec, K. - Havelek, R. - Kuličková, Jarmila - Řezanka, P. - Kaman, Ondřej
Magnetic oxide particles with gold nanoshells: synthesis, properties and cytotoxic effects.
Colloids and Surfaces A-Physicochemical and Engineering Aspects. Roč. 520, May (2017), s. 922-932. ISSN 0927-7757. E-ISSN 1873-4359
R&D Projects: GA ČR GA16-04340S
Institutional support: RVO:68378271
Keywords : cytotoxicity * core-shell nanoparticles * Mn-Zn ferrite * gold nanoshells * magnetic nanoparticles * surface plasmon resonance
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.829, year: 2017

A successful synthesis and detailed study of complex Mn-Zn ferrite core-shell nanoparticles, whose shell is composed of primary silica layer and secondary gold coating, are presented. Magnetic cores Mn0.61Zn0.42Fe1.98O4 are synthesized as a single-phase product by hydrothermal procedure. The cores are embedded in amorphous silica, and gold shell is formed on their surface by a seed-and-growth synthesis. EDS, ICP-MS, and magnetometry provide coherent results on the chemical composition. Colloidal stability of the complex particles in water is evidenced by DLS. 4-mercaptobenzoic acid and 7-mercapto-4-methylcoumarin are covalently attached to the surface of the particles. Both the molecules provide strong SERS signals, and the particles modified with the coumarin derivate constitute an efficient label for fluorescence microscopy. Finally, biological study on two different cell lines is carried out, dealing with the viability and real-time monitoring of proliferation and adhesion of cells.

Permanent Link: http://hdl.handle.net/11104/0286720