Integrins promote axonal regeneration after injury of the nervous system

0492415 - ÚEM 2019 RIV GB eng J - Journal Article
Nieuwenhuis, B. - Haenzi, B. - Andrews, M. R. - Verhaagen, J. - Fawcett, James
Integrins promote axonal regeneration after injury of the nervous system.
Biological Reviews. Roč. 93, č. 3 (2018), s. 1339-1362. ISSN 1464-7931. E-ISSN 1469-185X
R&D Projects: GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : axon regeneration * integrin * kindlin * receptor activation state
OECD category: Neurosciences (including psychophysiology
Impact factor: 10.288, year: 2018

Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
Permanent Link: http://hdl.handle.net/11104/0285963