Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.

Szczurowska, E.; Ahuja, Nikhil; Jiruška, Přemysl; Kelemen, E.; Stuchlík, Aleš

doi:https://dx.doi.org/10.1016/j.pnpbp.2017.09.013

Number of the records: 1

Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.

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SYSNO ASEP	0489341
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.
Author(s)	Szczurowska, E. (CZ) Ahuja, Nikhil (FGU-C)_{RID, ORCID, SAI} Jiruška, Přemysl (FGU-C)_{RID, ORCID, SAI} Kelemen, E. (CZ) Stuchlík, Aleš (FGU-C)_{RID, ORCID}
Source Title	Progress in Neuro-Psychopharmacology & Biological Psychiatry. - : Elsevier - ISSN 0278-5846 Roč. 81, Feb 2 (2018), s. 275-283
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	psychosis ; MK-801 ; neuronal discoordination ; hippocampus ; Theta rhythm
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	GA17-04047S GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000414901100032
EID SCOPUS	85029675626
DOI	10.1016/j.pnpbp.2017.09.013
Annotation	The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including 'hallmark' cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15 mg/kg dizocilpine (MK-801), an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2019

Number of the records: 1