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Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38
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SYSNO ASEP 0488579 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38 Author(s) Karmous, I. (TN)
Plesník, J. (CZ)
Khan, A. S. (FR)
Šerý, Omar (UZFG-Y) RID
Abid, A. (TN)
Mankai, A. (TN)
Aouidet, A. (TN)
Khan, N. A. (FR)Source Title Clinical Nutrition. - : Churchill Livingstone - ISSN 0261-5614
Roč. 37, č. 1 (2018), s. 313-320Number of pages 8 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords obesity ; fat taste ; bitter taste ; genetic polymorphism Subject RIV ED - Physiology OECD category Physiology (including cytology) Institutional support UZFG-Y - RVO:67985904 UT WOS 000425564200041 DOI 10.1016/j.clnu.2017.06.004 Annotation Background & aims: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects.
Design: The normal weight (n = 52, age = 35.3 +/- 4.10 years, BMI = 23.22 +/- 1.44 kg/m(2)) and obese (n = 52, age = 35.0 +/- 5.43 years, BMI = 34.29 +/- 531 kg/m(2)) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleotide polymorphism (SNP) of CD36 (rs1761667) and TAS2R38 (rs1726866 and rs10246939).
Results: The study included the participants who could detect LA, i.e., lipid-tasters. There was a positive correlation between BMI and detection thresholds for fat and bitter taste in normal weight and obese subjects. Obese participants showed a positive correlation between LA and PROP detection thresholds. PROP detection thresholds were higher for CD36 SNP (rs1761667) and TAS2R38 SNPs (rs1726866 and rs10246939) in obese participants compared to normal weight subjects. LA detection thresholds were not high for CD36 SNP (rs1761667) or TAS2R38 SNP (rs1726866 and rs10246939) in obese participants.
Conclusions: Orosensory detection thresholds for fat and bitter taste are associated with BMI, and CD36 and TAS2R38 genotypes are not always associated with taste phenotypes.Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2019
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