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Static high-gradient magnetic fields affect the functionality of monocytic cells
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SYSNO ASEP 0486097 R&D Document Type O - Ostatní Title Static high-gradient magnetic fields affect the functionality of monocytic cells Author(s) Syrovets, T. (DE)
Schmidt, Z. (DE)
Buechele, B. (DE)
Zablotskyy, Vitaliy A. (FZU-D) RID
Dejneka, Alexandr (FZU-D) RID, ORCID
Dempsey, N. (FR)
Simmet, T. (DE)Number of authors 7 Source Title FASEB JOURNAL, 2. - BETHESDA : FEDERATION AMER. SOC. EXP. BIOL., 2014 - ISSN 0892-6638
Roč. 28, č. 1 (2014), s. 1-2Number of pages 2 s. Language eng - English Country US - United States Keywords static high-gradient ; magnetic fields ; affect the functionality ; monocytic cells Subject RIV BM - Solid Matter Physics ; Magnetism OECD category Condensed matter physics (including formerly solid state physics, supercond.) Institutional support FZU-D - RVO:68378271 UT WOS 000346651000058 Annotation Magnetic fields, different to electric fields, can intrude into deeper layers of tissue, where they could modulate biochemical processes. In this context, we explored the cellular effects of specifically designed high-performance micro-magnet arrays which, in contrast to conventional magnets, generate high-gradient magnetic fields not encountered in the environment. Exposure of monocytic cells to high-gradient magnetic fields of various strength generated by micro-magnet arrays induced cell swelling followed by accumulation of reactive oxygen species (ROS), and inhibition of cell proliferation. High levels of ROS may damage cellular structures and induce apoptosis. Consistently, prolonged exposure of cells to high-gradient magnetic fields induced time-dependent translocation of phosphatidylserine to the outer leaflet of the membrane. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2018
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